Zhen Zhou 22/04/2025

Unveiling the processing mechanism of Hezi-decoction-processed Tiebangchui: a synthesis approach using UPLC-Q-TOF-MS-based metabolomics and DESI-MSI

Front Pharmacol. 2025 Apr 7;16:1534748. doi: 10.3389/fphar.2025.1534748. eCollection 2025.ABSTRACTINTRODUCTION: Tiebangchui (TBC, Tibetan name: བང་ང་ནག་པ།), the dried tuberous root of Aconitum pendulum Busch. and Aconitum flavaum Hand.-Mazz., is a prevalent used Tibetan medicine, recognized for its

Z Zhen Zhou
Keke Guo 22/04/2025

Total synthesis enabled structure revision of sesquiterpenoids

Org Biomol Chem. 2025 Apr 22. doi: 10.1039/d5ob00282f. Online ahead of print.ABSTRACTSesquiterpenoids have attracted the attention of chemists and biologists due to their unique structures and potential biological activities. Because of the complexity of their structures, many sesquiterpenoids have

K Keke Guo
Xiaotong Du 21/04/2025

Structure-guided evolution to improve the catalytic performance of aldo-keto reductase yhdN from Bacillus subtilis for preparing chiral diaryl α-hydroxy amides

Int J Biol Macromol. 2025 Apr 19:143381. doi: 10.1016/j.ijbiomac.2025.143381. Online ahead of print.ABSTRACTOptical diaryl α-hydroxy amides are valuable motifs for synthesis of chiral pharmaceuticals. Affected by the two bulky aryl substituents, their preparation by enantioselective carbonyl reducti

X Xiaotong Du
Christian Peez 21/04/2025

Evaluating the safety, pharmacokinetics and efficacy of phage therapy in treating fracture-related infections with multidrug-resistant Staphylococcus aureus: intravenous versus local application in sheep

Front Cell Infect Microbiol. 2025 Apr 4;15:1547250. doi: 10.3389/fcimb.2025.1547250. eCollection 2025.ABSTRACTBACKGROUND: Fracture-related infections (FRI), particularly those caused by antibiotic resistant Staphylococcus aureus, present significant clinical challenges due to the formation of biofil

C Christian Peez
Bolesław Szadkowski 19/04/2025

Improving compatibility between coffee or black tea ground wastes and polymer matrix via silane treatment for production sustainable biofillers

Sci Rep. 2025 Apr 19;15(1):13554. doi: 10.1038/s41598-025-97980-7.ABSTRACTThe incorporation of bio-waste products into polymer materials as a fillers and colorants represents a highly significant approach for developing sustainable composites, aligning with the principles of a circular bioeconomy an

B Bolesław Szadkowski
Robin Wolke 18/04/2025

Validity of tremor analysis using smartphone compatible computer vision frameworks

Sci Rep. 2025 Apr 18;15(1):13391. doi: 10.1038/s41598-025-97252-4.ABSTRACTComputer vision (CV)-based approaches hold promising potential for the classification and quantitative assessment of movement disorders. To take full advantage of this potential, the pipelines need to be validated against esta

R Robin Wolke
Steve Yadlowsky 18/04/2025

Evaluating Treatment Prioritization Rules via Rank-Weighted Average Treatment Effects

J Am Stat Assoc. 2025;120(549):38-51. doi: 10.1080/01621459.2024.2393466. Epub 2024 Oct 11.ABSTRACTThere are a number of available methods for selecting whom to prioritize for treatment, including ones based on treatment effect estimation, risk scoring, and hand-crafted rules. We propose rank-weight

S Steve Yadlowsky
Adam Stepniewski 18/04/2025

Local and regional flaps in scalp reconstructions: A retrospective analysis

JPRAS Open. 2025 Mar 14;44:291-299. doi: 10.1016/j.jpra.2025.03.005. eCollection 2025 Jun.ABSTRACTThe study demonstrates the broad applicability of local and regional flaps for the treatment of scalp defects of varying size and etiology. We aimed to verify whether the following variables correlate w

A Adam Stepniewski